Attendees to a January 2019 DCRI Think Tank outlined recommendations for optimizing pragmatic clinical trials and weighing risks and benefits of innovative trial designs. Read more from the Duke Clinical Research Institute>>

IGNITE hit a major milestone on July 10, 2020: The University of Florida randomized the first patient in to the GUARDD-US pragmatic clinical trial. Genetic testing to Understand Renal Disease Disparities across the US (GUARDD-US) will investigate the results of apolipoprotein L1 (APOL1) genotyping in an African American population. The primary outcome is systolic blood pressure (SBP) at three months comparing patients with high-risk APOL1 variants (positives) versus no high-risk variants (negatives). The co-primary outcome is three-month SBP in positives versus those ...

With a new decade dawning, Duke Today asked several Duke professors to hypothetically gaze into their crystal balls to tell us what they see happening in the years ahead. CAGPM director Geoff Ginsburg gave his perspective on what he thinks precision medicine will look like in a decade. Read more>>

The National Human Genome Research Institute (NHGRI) invites qualified physicians, physician assistants, nurse practitioners and genetic counselors to apply to the Fellowship in Genomic Medicine Program Management. This is an NIH coalition consisting of the National Human Genome Research Institute (NHGRI), the National Heart, Lung, and Blood Institute (NHLBI), the National Institute on Minority Health and Health Disparities (NIMHD), and the All of Us Research Program in partnership with the American College of Medical Genetics (ACMG). The goal of this fellowship is to increase the pool ...

As CEO, Denny will oversee NIH’s efforts to build one of the largest and most comprehensive precision medicine research platforms in the world, in partnership with a diverse network of awardees and participants. Read the announcement from NIH Director Francis Collins, M.D., Ph.D.

Getting diagnosed with a disease can be scary. Health providers work to find the right treatment plan based on the current standard of care guidelines. But what if in addition to the current evidence, doctors could also factor in each patient’s unique genetic makeup to help them diagnose more quickly and accurately, create a tailored treatment plan, or better yet, learn which patients are at a higher risk for developing specific diseases and employ methods for prevention or earlier detection? ...

Members of the IGNITE Network were involved in three of the five publications in this series. Genomic Medicine 1: Opportunities, resources and techniques for implementing genomics in clinical care describes the major types and measurement tools of genomic variation that are currently of clinical importance, reviews approaches to interpreting genomic sequence variants, identifies publicly available tools and resources for genomic test interpretation, and discusses several key barriers in using genomic information in routine clinical practice. Genomic Medicine 4: Family health history: Underused for ...