GMKBMichael T. Eadon, MD; Kerri L. Cavanaugh, MD, MHS; Lilin She, PhD
- DOI: 10.1001/jamanetworkopen.2026.0528
- Article on Jama Network
Design and rationale of GUARDD-US: A pragmatic, randomized trial of genetic testing for APOL1 and pharmacogenomic predictors of antihypertensive efficacy in patients with hypertension
- PMID: 35660539
- DOI: 10.1016/j.cct.2022.106813
Effects of Testing and Disclosing Ancestry-Specific Genetic Risk for Kidney Failure on Patients and Health Care Professionals: A Randomized Clinical Trial
Nadkarni, G. N., Fei, K., Ramos, M. A., Hauser, D., Bagiella, E., Ellis, S. B., Sanderson, S., Scott, S. A., Sabin, T., Madden, E., Cooper, R., Pollak, M., Calman, N., Bottinger, E. P., & Horowitz, C. R.
CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention in Diverse Clinical Settings
PMID: 35156424 DOI: 10.1161/JAHA.121.024159
Multi-Institutional Implementation of Clinical Decision Support for APOL1, NAT2, and YEATS4 Genotyping in Antihypertensive Management.
Schneider TM, Eadon MT, Cooper-DeHoff RM, Cavanaugh KL, Nguyen KA, Arwood MJ, Tillman EM, Pratt VM, Dexter PR, McCoy AB, Orlando LA, Scott SA, Nadkarni GN, Horowitz CR, Kannry JL.
J Pers Med. 2021 May 27;11(6):480. doi: 10.3390/jpm11060480.
PMID: 34071920
Establishing the value of genomics in medicine: the IGNITE Pragmatic Trials Network
A critical gap in the adoption of genomic medicine into medical practice is the need for the rigorous evaluation of the utility of genomic medicine interventions.
Opportunity for Genotype-Guided Prescribing Among Adult Patients in 11 US Health Systems
J. Kevin Hicks, Nihal El Rouby,Henry H. Ong, Jonathan S. Schildcrout, Laura B. Ramsey, Yaping Shi,Leigh Anne Tang, Christina L. Aquilante,Amber L. Beitelshees, Kathryn V. Blake, James J. Cimino,Brittney H. Davis, Philip E. Empey, David P. Kao,Daniel L. Lemkin, Nita A. Limdi, Gloria P. Lipori, Marc B. Rosenman, Todd C. Skaar, Evgenia Teal, Sony Tuteja, Laura K. Wiley, Helen Williams, Almut G. Winterstein, Sara L. Van Driest, Larisa H. Cavallari, Josh F. Peterson, on behalf of the IGNITE Pharmacogenetics Working Group
Physician-Reported Benefits and Barriers to Clinical Implementation of Genomic Medicine: A Multi-Site IGNITE-Network Survey
Journal of Personalized Medicine – To understand potential barriers and provider attitudes, we surveyed 285 physicians from five Implementing GeNomics In pracTicE (IGNITE) sites about their perceptions as to the clinical utility of genetic data as well as their preparedness to integrate it into practice.
Determining the effects and challenges of incorporating genetic testing into primary care management of hypertensive patients with African ancestry
Horowitz CR, Abul-Husn NS, Ellis S, Ramos MA, Negron R, Suprun M, Zinberg RE, Sabin T, Hauser D, Calman N, Bagiella E, Bottinger EP
The IGNITE network: a model for genomic medicine implementation and research
BMC Medical Genetics – Patients, clinicians, researchers and payers are seeking to understand the value of using genomic information (as reflected by genotyping, sequencing, family history or other data) to inform clinical decision-making. However, challenges exist to widespread clinical implementation of genomic medicine, a prerequisite for developing evidence of its real-world utility.