GMKBQualitative Report – This study’s purpose was to develop a typology of subgroups of patients who share common patterns of medication exposure. To create the typology, we used an exemplar sample of 30 patients in a large public healthcare system who had been prescribed the pharmacogenetically actionable opioids codeine or tramadol.
Physician-Reported Benefits and Barriers to Clinical Implementation of Genomic Medicine: A Multi-Site IGNITE-Network Survey
Journal of Personalized Medicine – To understand potential barriers and provider attitudes, we surveyed 285 physicians from five Implementing GeNomics In pracTicE (IGNITE) sites about their perceptions as to the clinical utility of genetic data as well as their preparedness to integrate it into practice.
Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network
Genetics in Medicine – Here we describe the findings from the National Human Genome Research Institute’s (NHGRI) Implementing GeNomics In pracTicE (IGNITE) Network in identifying key constructs, opportunities, and challenges associated with driving sustainability of genomic medicine in clinical practice.
Implementation, adoption, and utility of family health history risk assessment in diverse care settings: evaluating implementation processes and impact with an implementation framework
Genetics in Medicine – This paper describes the implementation outcomes associated with integrating a family health history–based risk assessment and clinical decision support platform within primary care clinics at four diverse healthcare systems.
Views Of Primary Care Providers On Testing Patients For Genetic Risks For Common Chronic Diseases
Health Affairs – We surveyed 488 primary care providers in community and academic practices in New York City in the period 2014–16 about their views on genetic testing for chronic diseases.
Educational strategies to enable expansion of pharmacogenomics-based care
American Journal of Health-System Pharmacy – This review summarizes requisite pharmacist competencies, educational standards, and the current state of pharmacogenomics education to propose best practice solutions for educators to meet the specific needs and challenges of this complex topic.
Role of genetic testing in patients undergoing percutaneous coronary intervention
Expert Review of Clinical Pharmacology – The present manuscript provides an overview of genetic factors associated with response profiles to platelet P2Y12 receptor inhibitors and their clinical implications, as well as the most recent developments and future considerations on the role of genetic testing in patients undergoing PCI.
Developing a Common Framework for Evaluating the Implementation of Genomic Medicine Interventions in Clinical Care: The IGNITE Network’s Common Measures Working Group
Genetics in Medicine – This paper describes the Implementing GeNomics In PracTicE (IGNITE) Network’s efforts to promote: 1) a broader understanding of genomic medicine implementation research; and 2) the sharing of knowledge generated in the network.
Personalizing antiplatelet prescribing using genetics for patients undergoing percutaneous coronary intervention
Expert Review of Cardiovascular Therapy – This article describes the impact of CYP2C19 genotype on clopidogrel pharmacokinetics, pharmacodynamics, and effectiveness.
IGNITE Network analysis of challenges to implementing genomics in practice featured on GenomeWeb
GenomeWeb – Duke University led this effort to identify key challenges to and potential solutions for implementing genomics in practice based on information from IGNITE’s six member projects. (A free subscription is required to view this article.)