GMKBJournal of Community Genetics – Structured interviews, including open-ended and closed-ended questions, were conducted with 205 patients in an inner-city hospital outpatient clinic.
Collection of family health history for chronic diseases in primary care
North Carolina Medical Journal – Family health history can predict a patient’s risk for common complex diseases. This project assessed the completeness of family health history data in medical charts and evaluated the utility of these data for performing risk assessments in primary care.
Patient and primary care provider experience using a family health history collection, risk stratification, and clinical decision support tool: a type 2 hybrid controlled implementation-effectiveness trial
BMC Family Practice – Family health history (FHH) is the single strongest predictor of disease risk and yet is significantly underutilized in primary care. We developed a patient facing FHH collection tool, MeTree©, that uses risk stratification to generate clinical decision support for breast cancer, colorectal cancer, ovarian cancer, hereditary cancer syndromes, and thrombosis.
Collection of family health history for assessment of chronic disease risk in primary care.
North Carolina Medical Journal – Family health history can predict a patient’s risk for common complex diseases. This project assessed the completeness of family health history data in medical charts and evaluated the utility of these data for performing risk assessments in primary care.
Development and Validation of a Primary Care-Based Family Health History and Decision Support Program (MeTree)
North Carolina Medicine Journal – Family health history is a strong predictor of disease risk. To reduce the morbidity and mortality of many chronic diseases, risk-stratified evidence-based guidelines strongly encourage the collection and synthesis of family health history to guide selection of primary prevention strategies. However, the collection and synthesis of such information is not well integrated into clinical practice. To address barriers to collection and use of family health histories, the Genomedical Connection developed and validated MeTree, a Web-based, patient-facing family health history collection and clinical decision support tool.
The Genomic Medicine Model: An Integrated Approach to Implementation of Family Health History in Primary Care
Personalized Medicine – As an essential tool for risk stratification, family health history (FHH) is a central component of personalized medicine; yet, despite its widespread acceptance among professional societies and its established place in the medical interview, its widespread adoption is hindered by three major barriers: quality of FHH collection, risk stratification capabilities and interpretation of risk stratification for clinical care.
The CLIPMERGE PGx Program: clinical implementation of personalized medicine through electronic health records and genomics-pharmacogenomics
Clinical Pharmacology & Therapeutics – The CLIPMERGE PGx Program is establishing a best-practices infrastructure for implementation of genome-informed prescribing using a biobank-derived clinical cohort, pre-emptive genetic testing, and real-time clinical decision support deployed through the electronic health record.